Abstract
Since the introduction of the first antibiotic, the quick development of resistance has threatened the efficacy of such medications. Improving antibiotic use is, above all, a patient safety issue. As frontline health care providers, nurses can become more engaged and take a leadership role to enhance antibiotic stewardship programs. The unrecognized role of nurses in antibiotic stewardship efforts is just beginning to be explored. From hospital to home settings, the breadth of infusion nurse practice positions them to take principal roles in antibiotic stewardship program development across the continuum of care.