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artificial dermis, chronic ulcer, hydroxyurea, leg ulcer, platelet-rich plasma, thrombocythemia



  1. Zhao, Qiannan MA
  2. Ma, Yuanyuan MD
  3. Lu, Yuquan PhD
  4. Chai, Yuan MD
  5. Zhou, Yuemin PhD, MD


ABSTRACT: Hydroxyurea is an oral medication associated with painful, nonhealing ulcers, for which there is no effective treatment but permanent discontinuation of hydroxyurea. The authors present a case of leg ulcers that likely occurred as a result of hydroxyurea use in a patient with essential thrombocythemia. Topical treatment with allogeneic platelet-rich plasma and artificial dermis completely healed the leg ulcers without hydroxyurea cessation.