1. Armahizer, Michael J. PharmD, BCCCP
  2. Strein, Micheal PharmD, BCPS, BCCCP
  3. Pajoumand, Mehrnaz PharmD, BCPS, BCCCP


Targeted temperature management (TTM) is used frequently in patients with a variety of diseases, especially those who have experienced brain injury and/or cardiac arrest. Shivering is one of the main adverse effects of TTM that can often limit its implementation and efficacy. Shivering is the body's natural response to hypothermia and its deleterious effects can negate the benefits of TTM. The purpose of this article is to provide an overview of TTM strategies and shivering management.