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biomaterial, chronic wounds, cellular and/or tissue-based product, extracellular matrix, ovine forestomach matrix, wound healing, wound management



  1. Raizman, Rose RN-EC, NSWOC, MSc
  2. Hill, Rosemary RN, CWOCN, CETN(C)
  3. Woo, Kevin PhD, RN, NSWOC, WOCC(C), FAPWCA


OBJECTIVE: To evaluate an advanced extracellular matrix made of ovine forestomach matrix (OFM) for healing a variety of wound types.


METHODS: Participants were enrolled from inpatient, outpatient, and home healthcare settings. The OFM was used to treat all wounds and applied to the wound bed every 3 to 7 days until closure.


RESULTS: Researchers enrolled 29 participants with 33 wounds. Average time to wound closure was 8.2 weeks, the percentage of wounds that reduced in size by 50% or more at 4 weeks was 64%, the average wound area reduction at 4 weeks was 66%, and 73% of wounds had closed at 12 weeks. No adverse effects were observed.


CONCLUSIONS: This represents the first Canadian evaluation of OFM for the treatment of wounds, and the positive healing outcomes observed could support more widespread adoption of this matrix.