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Update on cancer in the United States. Overall cancer death rates in the United States have declined for all age and racial and ethnic groups, according to the Annual Report to the Nation on the Status of Cancer, a collaboration of the American Cancer Society, Centers for Disease Control and Prevention, National Cancer Institute, and North American Association of Central Cancer Registries. Death rates decreased for 11 of the 19 most common cancers in men and 14 of the 20 most common cancers in women. The greatest decrease in death rates was seen for melanoma, the result of new targeted drug and immune therapies. Lung cancer death rates had the second greatest decline, due to reduction in tobacco smoking and new treatments, though lung cancer still has the highest death rate of all cancers. Not all cancer death rates are declining; previous trends in declining death rates reversed or slowed in cancers related to obesity, including colorectal and female breast cancers. Racial disparities continue: though overall incidence of cancer is higher in White people, death rates are higher in Black people. This is particularly true for female breast cancer, with Black women dying at rates 40% higher than White women despite similar incidence rates.