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  1. Beaudry, Rhys I. PhD
  2. Akins, John D. MSc
  3. Richey, Rauchelle E. MSc
  4. Brothers, R. Matthew PhD
  5. Nelson, Michael D. PhD
  6. Sarma, Satyam MD
  7. Tucker, Wesley J. PhD
  8. Haykowsky, Mark J. PhD, FACC, FAHA


Purpose: The objective of this investigation was to compare the acute hemodynamic responses during single-leg knee extension (SLKE) exercise between female breast cancer (BC) survivors previously treated with anthracycline chemotherapy and age- and sex-matched control (CON) subjects.


Methods: Fourteen BC survivors (age: 61 +/- 7 yr; time post-anthracycline therapy: 12 +/- 6 yr) and nine CON subjects (age: 59 +/- 7 yr) performed SLKE exercise at 25%, 50%, and 75% of peak power output during which heart rate, blood pressure (BP), leg blood flow (Doppler ultrasonography), and vascular conductance (leg blood flow/mean BP) were measured. Quadriceps mass was estimated from thigh volume and skinfold measures.


Results: Breast cancer survivors had lower quadriceps mass compared with CON subjects (1803 +/- 607 vs 2601 +/- 1102 g, P = .04). No difference was found between groups for maximal SLKE power output (28 +/- 11 vs 34 +/- 17 W, P = .35), heart rate (109 +/- 14 vs 103 +/- 13 bpm, P = .36), or mean arterial BP (122 +/- 18 vs 119 +/- 26 mm Hg, P = .33). Rest and submaximal exercise mean arterial BP, leg blood flow (indexed to quadriceps muscle mass), and leg vascular conductance were not significantly different between BC survivors and CON subjects.


Conclusion: Leg blood flow during submaximal SLKE exercise is preserved in long-term BC survivors previously treated with anthracycline chemotherapy.