Abstract
Postoperative anastomotic leakage following surgery for colorectal cancer is a serious complication that is frequently associated with significant intra-abdominal infection and the formation of peristomal abscesses. Patients with this condition often present with complex medical comorbidities and face considerable challenges in achieving wound healing. In this case report, a 57-year-old man presented with colonic obstruction secondary to colon cancer and subsequently underwent curative surgery. Postoperatively, anastomotic leakage occurred, which necessitated resection of the anastomosis and the formation of a descending colostomy. The patient subsequently developed severe intra-abdominal infection and peristomal abscess, leading to impaired wound healing. Clinicians implemented a treatment regimen combining continuous negative-pressure wound therapy (NPWT) with intermittent NPWT with instillation and dwell time. This approach resulted in rapid wound healing. Ultimately, the patient successfully underwent colostomy closure, restoring gastrointestinal continuity. For abdominal wounds with severe fecal contamination and extensive separation of the dermis and subcutaneous tissues, the combination of continuous NPWT and intermittent NPWT with instillation and dwell time may be an efficacious therapeutic strategy.