Abstract
The opioid epidemic remains a significant public health challenge in the United States. Nurse practitioners (NPs) play a crucial role in addressing this crisis. This article discusses the implications for NPs of the Centers for Disease Control and Prevention 2022 updated clinical practice guideline on opioid prescribing, focusing on four key areas: 1) deciding whether to initiate opioids, 2) determining appropriate opioids and dosages, 3) determining treatment duration and follow-up, and 4) implementing risk assessment and mitigation strategies. Adhering to this guideline enables NPs to optimize opioid prescribing practices and deliver patient-centered care that aligns with public health priorities to combat the opioid crisis.