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  1. McCloskey, William W. PharmD, RPh
  2. Zaiken, Kathy PharmD, RPh
  3. Couris, R. Rebecca PhD, RPh


Grapefruit juice is typically consumed in the morning at the same time that many patients take their medications. Therefore, there is a concern among healthcare professionals that this may result in clinically significant drug interactions. This article reviews the current understanding of drug-grapefruit juice interactions and those drugs most likely to be affected by the ingestion of grapefruit juice.