Physician's Briefing Weekly Coronavirus Roundup
Friday, May 29, 2020
Remdesivir Use Growing Globally in COVID-19 Patients
Yet, most physicians believe it is only moderately effective, better used earlier than official guidelines recommend
Friday, May 29, 2020
VA Slashes Use of Hydroxychloroquine to Treat COVID-19 Patients
Prescribing reduced to just three prescriptions in the last week as new research highlights possible dangers
Friday, May 29, 2020
Burden of Severe COVID-19 High in California, Washington State
Length of stay was 9.3 days for survivors; probability high for ICU admission, mortality
Friday, May 29, 2020
Five-Day Course of Remdesivir Beneficial in Severe COVID-19
No significant difference seen in five-, 10-day course for severe COVID-19 without mechanical ventilation
Friday, May 29, 2020
Parents Facing Higher Levels of Stress During Pandemic
Pandemic-related stress also disproportionately impacting communities of color
Thursday, May 28, 2020
CDC: Coronavirus Antibody Tests Still Not Accurate Enough
Too little is known about what the presence of antibodies means in terms of future immunity
Thursday, May 28, 2020
9.5 Percent Uninsured in U.S. From January Through June 2019
Overall, 13.7 percent of adults aged 18 to 64, 4.4 percent of children aged 0 to 17 were uninsured
Thursday, May 28, 2020
CV Toxicity Tied to Azithromycin and/or Hydroxychloroquine
Risk increased for prolonged QT and/or ventricular tachycardia, including torsades de pointes
Thursday, May 28, 2020
Parents Struggling to Provide for Families During Pandemic
Hardships greatest for low-income, Hispanic, and black parents
Wednesday, May 27, 2020
Only One in Four U.S. Hospitals With ICUs Have Tele-ICU Services
Wide regional variation seen for availability of telehealth outpatient visits, tele-ICU services
Wednesday, May 27, 2020
African-Americans More Likely to Be Hospitalized With COVID-19
Odds of hospitalization increased 2.7-fold versus non-Hispanic whites after adjustment for age, sex, comorbidity
Wednesday, May 27, 2020
U.K. Patients Hospitalized With COVID-19 Are More Often Male
In-hospital mortality higher with increasing age, male sex, comorbidities such as liver disease, obesity
Wednesday, May 27, 2020
WHO Suspends Testing of Hydroxychloroquine in COVID-19 Patients
In light of recent findings, hydroxychloroquine arm of WHO global study paused temporarily
Tuesday, May 26, 2020
Placental Injury Seen in Pregnant Women With SARS-CoV-2
Higher rates of decidual arteriopathy, other maternal vascular malperfusion features observed
Tuesday, May 26, 2020
Adenovirus Type-5 Vectored COVID-19 Vaccine Shows Promise
ELISA antibodies and neutralizing antibodies increased at day 14, peaked at day 28
Tuesday, May 26, 2020
Hydroxychloroquine Plus Macrolides No Benefit in COVID-19
Hydroxychloroquine, chloroquine with or without macrolides linked to in-hospital mortality, arrhythmia
Tuesday, May 26, 2020
Remdesivir Beats Placebo for Time to COVID-19 Recovery
Researchers suggest antiviral agents in combination with other therapeutic approaches may further improve outcomes
Tuesday, May 26, 2020
Physician's Briefing Weekly Coronavirus Roundup
Friday, May 22, 2020
Age, Sex, History of Diabetes Predict Intubation in COVID-19
Only factors independently associated with time to extubation are age and body mass index
Friday, May 22, 2020
U.S. Offers $1.2 Billion to Drug Company for COVID-19 Vaccine Research
Deal will fund phase 3 clinical trial in the United States this summer with about 30,000 volunteers
Friday, May 22, 2020
U.S. Government Seeks Deal With Private Industry to Boost Supply of Medical Equipment
Agreement would ensure country has adequate supplies of protective gear, medical equipment, medicine, vaccines
Friday, May 22, 2020
CDC: COVID-19 Not Spread Easily From Contaminated Surfaces
Updated information from the agency also outlines what is not considered to pose a high risk for infection
Friday, May 22, 2020
ED Chest X-Ray Score Predicts COVID-19 Outcomes in Adults <50
CXR severity score ≥2 and obesity independent predictors of hospital admission
Friday, May 22, 2020
Cardiac Decompensation Seen in Children Following COVID-19
Cardiac decompensation occurred in conjunction with multisystem inflammatory syndrome in some children
Friday, May 22, 2020
No SARS-CoV-2 ID'd in Asymptomatic Pregnant Women in Los Angeles
Among 80 asymptomatic pregnant women admitted to Cedars-Sinai Medical Center, none tested positive
Friday, May 22, 2020
Rate of Stroke Low in Hospitalized Patients With COVID-19
Cryptogenic strokes more common, mortality higher in COVID-19 patients than in controls with stroke
Thursday, May 21, 2020
CDC: Live Poultry Linked to Salmonella Cases in 28 States
17 hospitalizations reported, but no deaths reported; children younger than 5 account for one-third of ill people
Thursday, May 21, 2020
CDC Says Test All Newborns of Mothers With Confirmed, Suspected COVID-19
Newborns should be tested 24 hours after birth and, if the test is negative, be retested the next day
Thursday, May 21, 2020
Asthma Tied to Longer COVID-19 Intubation Time
However, asthma not associated with higher rates of acute respiratory distress syndrome, death
Thursday, May 21, 2020
Musculoskeletal Malformations Up With Fluconazole in Pregnancy
But no increase seen in conotruncal malformations, oral clefts with use of oral fluconazole in first trimester
Thursday, May 21, 2020
Decrease Seen in Child Vaccination Coverage During COVID-19
Up-to-date status for all recommended vaccines down to 49.7 percent among children aged 5 months
Wednesday, May 20, 2020
Some Children With COVID-19 Require Admission, PICU Care
Elevated CRP, procalcitonin, pro-BNP, platelet count -- but not obesity, asthma -- linked to PICU admission
Wednesday, May 20, 2020
Age, CRP Up Risk for Mortality in Diabetes With COVID-19
Insulin usage linked to poor prognosis; ACEI/ARB use did not impact clinical outcome in those with HTN
Wednesday, May 20, 2020
Obesity Tied to Increased Risk for Progression to Severe COVID-19
Authors urge close monitoring, prompt treatment for obese patients with COVID-19
Tuesday, May 19, 2020
Mental Health Symptoms Up for Medics Dealing With COVID-19
Mean Symptom Checklist-90 score significantly higher for medical personnel responding to COVID-19
Tuesday, May 19, 2020
CMS: Use 'Extreme Caution' in Reopening Nursing Homes
There have been more than 33,000 deaths due to coronavirus outbreaks in U.S. nursing homes
Tuesday, May 19, 2020
Spending on Primary Care Continues to Lag in the U.S.
Authors say increasing investment in primary care could slow future health care spending growth
Tuesday, May 19, 2020
Hydroxychloroquine Does Not Improve COVID-19 Pneumonia Outcomes
Second study shows no benefit versus standard of care in probability of negative conversion by 28 days
Tuesday, May 19, 2020
28 Million-Plus Surgeries Could Be Canceled Due to COVID-19
About 45 weeks needed to clear surgery backlog if countries up surgical volume by 20 percent later
Tuesday, May 19, 2020
Factors ID'd for Positive SARS-CoV-2 Test Result in Primary Care
Sociodemographic risk factors include male sex, deprivation, population density, ethnicity, obesity
Tuesday, May 19, 2020
Social Distancing Policies Reduced COVID-19 Growth Rate
Policies reduced daily COVID-19 growth rate by 5.4 and 6.8 percent after one to five, six to 10 days
Monday, May 18, 2020
Experimental COVID-19 Vaccine Appears Safe, Triggers Immune Response
Findings from early-stage trial that started in March and included eight healthy people receiving two doses
Monday, May 18, 2020
Guidance Issued for Osteoporosis Management During COVID-19
Alternative methods for parenteral treatments include off-site clinics, home visit, self-injection
Monday, May 18, 2020
Cough May Not Appear in Young Children With COVID-19
Digestive tract infection appears common in children hospitalized with COVID-19 in China
Monday, May 18, 2020
Convalescent Plasma Appears Promising for Severe COVID-19
In series of 25 patients, 19 experienced improvement in clinical status by day 14; 11 were discharged
Monday, May 18, 2020
Most Physicians Have Seen False-Negative COVID-19 Test Results
One in 10 physicians worldwide report seeing at least one case of COVID-19 reinfection
Monday, May 18, 2020
Physician's Briefing Weekly Coronavirus Roundup
Friday, May 15, 2020
COVID-19 Cases Increased More Rapidly With No Stay-at-Home Order in Iowa
Counties bordering Iowa in Illinois had slower increase in COVID-19 cases following stay-at-home order
Friday, May 15, 2020
FDA: Abbott Rapid COVID-19 Test Could Miss Infections
Research has suggested that the Abbott ID NOW point-of-care test may return false-negative results
Friday, May 15, 2020
NIH: Large-Scale Testing of Some COVID-19 Vaccines Could Start in July
About a dozen potential vaccines worldwide are in the initial stages of, or set to begin, testing in people
Friday, May 15, 2020
Interferon-α2b May Shorten Viral Shedding Duration in COVID-19
Duration of elevated blood levels for inflammatory markers IL-6, C-reactive protein also reduced
Friday, May 15, 2020
ACP Advises Against Chloroquine, Hydroxychloroquine for COVID-19
Practice points based on lack of evidence supporting use as prophylaxis or treatment for COVID-19
Friday, May 15, 2020
Kawasaki-Like Disease Incidence Up After Start of SARS-CoV-2
Children diagnosed after start of SARS-CoV-2 were older, had higher rate of cardiac involvement
Thursday, May 14, 2020
Opt-Out Universal Hep C Screening in Emergency Dept Is Useful
47.8 percent of cases reactive to HIV antibody were among those born after 1965
Thursday, May 14, 2020
Bowel Abnormalities Described in Inpatients With COVID-19
Bowel wall abnormalities identified on 31 percent of 42 CT scans, associated with ICU admission
Thursday, May 14, 2020
Guidance Issued for Acute Large Vessel CVA During COVID-19 Pandemic
Recommendations relate to prehospital care, pre-, intra-, postthrombectomy care
Thursday, May 14, 2020
Meta-Analysis Links Smoking to COVID-19 Disease Progression
Risk for COVID-19 progression nearly double for smokers versus nonsmokers
Thursday, May 14, 2020
COVID-19 Fatality Rate High for Heart Transplant Recipients
Of 28 infected HT recipients, 79 percent admitted for treatment, 25 percent needed mechanical ventilation
Thursday, May 14, 2020
Cannabis Smoking May Increase Risk for Fungal Infection
After adjustment for age, immunocompromised status, odds ratio of fungal infection was 3.5
Thursday, May 14, 2020
Doctors Should Watch for Pediatric Inflammatory Syndrome With COVID-19
Epidemiologists are developing a definition of the syndrome that could be released this week
Wednesday, May 13, 2020
Plan in Place to Up Production of Prefilled Syringes for Future COVID-19 Vaccine
Project Jumpstart aims to produce 100 million prefilled syringes by the end of 2020 and more than 500 million in 2021
Wednesday, May 13, 2020
Live Biotherapeutic Promising for Prevention of Bacterial Vaginosis
Following vaginal metronidazole for BV, incidence of recurrence lower with Lactin-V versus placebo
Wednesday, May 13, 2020
Sickness Presenteeism Common With Influenza-Like Illness
Most health care workers, non-HCWs continue to work when sick with ILI; more HCWs work with fever
Wednesday, May 13, 2020
Experts Discuss Strategy for Bariatric Surgery During COVID-19
Recommendations address nonsurgical management, prioritization of patients once surgery resumes
Wednesday, May 13, 2020
Addition of Zinc May Benefit Some Being Treated for COVID-19
Some outcomes improved with addition of zinc sulfate to hydroxychloroquine and azithromycin
Wednesday, May 13, 2020
Olfactory Dysfunction Most Often Occurs by Third Day of COVID-19
Loss of smell, usually severe and accompanied by loss of taste, may signal later shortness of breath
Tuesday, May 12, 2020
Risk Score May Predict Critical Illness at COVID-19 Admission
10 independent predictors in risk score include chest radiographic abnormality, age, hemoptysis, dyspnea
Tuesday, May 12, 2020
Doctors Without Borders Team Sent to Navajo Nation to Fight COVID-19
This marks the first time Doctors Without Borders has dispatched a team to a U.S. location
Tuesday, May 12, 2020
Established ARDS Therapy Aids Many Critically Ill With COVID-19
Findings seen in series of 66 patients with COVID-19 respiratory failure receiving mechanical ventilation
Tuesday, May 12, 2020
Severe Illness Reported in Some Children With COVID-19
83 percent of children admitted to 46 participating PICUs had significant preexisting comorbidities
Tuesday, May 12, 2020
Pediatric Vaccine Ordering Has Decreased During COVID-19
Decrease seen in VFC-funded APIC-recommended childhood vaccines after national emergency declaration
Tuesday, May 12, 2020
Crude Link ID'd for Vitamin D Levels, COVID-19 Cases, Death
Vitamin D levels severely low in aging population, the most vulnerable population to COVID-19
Tuesday, May 12, 2020
Hydroxychloroquine Has No Impact on Outcomes in COVID-19
No link seen between use of the drug and risk for composite end point of intubation or death
Monday, May 11, 2020
SARS-CoV-2 Spreads Rapidly Through Skilled Nursing Facilities
More than half of residents who tested positive were asymptomatic at time of testing
Monday, May 11, 2020
Anakinra May Reduce Systemic Inflammation in COVID-19
At 21 days, survival was 90 percent in anakinra group versus 56 percent in standard treatment group
Monday, May 11, 2020
Epidemic Growth of COVID-19 Not Linked to Latitude, Temperature
Slower epidemic growth strongly tied to restrictions of mass gatherings, school closure, social distancing
Monday, May 11, 2020
Triple Antiviral Therapy Promising for Mild-to-Moderate COVID-19
Duration of viral shedding shorter with combination of lopinavir-ritonavir, ribavarin, interferon beta-1b
Monday, May 11, 2020
Physician's Briefing Weekly Coronavirus Roundup
Friday, May 8, 2020
Most Jurisdictions Report COVID-19 in Correctional Facilities
86 percent of 54 state and territorial health department jurisdictions have one or more COVID-19 cases
Friday, May 8, 2020
Symptomatic COVID-19 Infection Fatality Rate 1.3 Percent in U.S.
County-specific infection fatality rates for symptomatic cases varied from 0.5 to 3.6 percent
Friday, May 8, 2020
FDA Slashes Number of Approved Chinese Makers of N95 Masks
Cut comes after officials found that many imported N95 masks did not meet U.S. standards
Friday, May 8, 2020
Asthma, COPD Medication Adherence Up During Pandemic
Authors say increased adherence may reflect patient concern about controlling primary respiratory illness
Friday, May 8, 2020
Deaths of Despair Likely to Increase During Pandemic
Authors propose policies addressing employment; access to care; and integrated behavioral, clinical care
Friday, May 8, 2020
Doubt Cast on Notion That New Strain of COVID-19 Is More Infectious
Former FDA head says research 'doesn't prove that this new strain is in fact more infectious'
Thursday, May 7, 2020
GI Symptoms Seen in Less Than 10 Percent of COVID-19 Patients
Outpatients with new-onset GI symptoms should be monitored for COVID-19 symptoms
Thursday, May 7, 2020
Health Care Workers at Risk From Mental Burden of COVID-19
Prevalence of anxiety symptoms higher for health care workers/young spending more time on outbreak
Wednesday, May 6, 2020
Human Trials of Experimental COVID-19 Vaccine Begin in U.S.
If effective, vaccine could be available for emergency use in the United States as early as September
Wednesday, May 6, 2020
New Coronavirus Strain More Contagious, Scientists Say
New strain spreads faster and may make people susceptible to a second COVID-19 infection
Wednesday, May 6, 2020
HIV+ Men Are Not Receiving STD Testing, Prevention Services
Men receiving HIV care still not receiving guideline-recommended sexually transmitted disease testing
Wednesday, May 6, 2020
Guideline Issued for Nonsevere, Severe COVID-19 Therapy
Corticosteroids recommended for severe COVID-19 with ARDS but not severe COVID-19 without ARDS
Wednesday, May 6, 2020
Well-Controlled Blood Glucose May Improve COVID-19 Outcomes
Mortality lower in hospitalized COVID-19 patients with T2DM who had well-controlled blood glucose
Wednesday, May 6, 2020
Michigan Nursing Homes More Prepared for Pandemics Than in 2007
Vast majority of registered nursing homes now have response plan and person responsible for administering it
Tuesday, May 5, 2020
USPSTF Recommends Hep B Screening for Those at Increased Risk
Screening for HBV has moderate net benefit in adolescents, adults at increased risk for infection
Tuesday, May 5, 2020
PPE With More Coverage Ups Protection, but Harder to Don, Doff
Modified gowns with attached gloves and gloves, masks with added tabs may cut contamination
Tuesday, May 5, 2020
Variation Seen in COVID-19 Tests, Hospitalization, Deaths Across NYC
Highest number of patients with COVID-19 who were hospitalized and number of deaths was in the Bronx
Tuesday, May 5, 2020
Race and Income Influence Risk for Severe COVID-19
Higher risk seen for black and American Indian versus white adults, for those living in low-income households
Tuesday, May 5, 2020
ACE Inhibitors, ARBs Not Linked to Risk for COVID-19
And, not one of five classes of anti-HTN meds linked to increased likelihood of positive COVID-19 test
Tuesday, May 5, 2020
FDA Goes After Unproven COVID-19 Antibody Tests
Companies selling tests will be required to submit data proving accuracy within next 10 days
Monday, May 4, 2020
Recommendations Made for PPE Use by HCPs in COVID-19 Care
Guidelines address mask, glove, face shield use in conventional, contingency, crisis capacity settings
Monday, May 4, 2020
With Many States Reopening, COVID-19 Testing Levels Still Too Low
Analysis shows that right now just 40 percent of states can meet the lower 2 percent threshold for testing
Monday, May 4, 2020
Posttraumatic Stress Symptoms Seen in China After COVID-19
People with poor sleep quality report higher rates of posttraumatic stress symptoms
Monday, May 4, 2020
Patients With Cancer Seem More Vulnerable to COVID-19
Frequency of severe events highest for patients with hematologic cancer, lung cancer, and metastatic cancer
Monday, May 4, 2020
Early Awake Proning for COVID-19 Improves Oxygen Saturation
Improvement in oxygen saturation seen with awake early self-proning in the emergency department
Monday, May 4, 2020
Hydroxychloroquine in COVID-19 Ups Risk for QTc Prolongation
Concurrent treatment with azithromycin linked to greater changes in corrected QT interval
Monday, May 4, 2020
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