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Conversations less often about flu or COVID-19 vaccines versus school-required vaccines

On World AIDS Day, White House Announces Plan to End Epidemic by 2030

Global goals include reaching UNAIDS targets for reducing new infections and reaching targets for all age, gender, and population groups

First FDA-Approved Fecal-Based Treatment Helps Fight C. difficile

Rebyota is prepared from human stool donated by qualified individuals

Temporal Improvement Seen in Standard of Care for Hospitalized COVID-19 Patients

Outcomes improved from Adaptive COVID-19 Treatment Trial-2 to ACTT-3, although potential explanatory factors were similar

Convection-Enhanced Delivery of Topotecan Active in Glioblastoma

Catheter pump system capable of CED of topotecan well tolerated and active in recurrent glioblastoma

RSNA: Corticosteroid Injections Appear to Worsen Knee Osteoarthritis

Corticosteroids linked to progression of knee OA based on whole-organ magnetic resonance imaging scores, KL grade

Six Additional Weeks of Rivaroxaban Reduces Recurrent VTE

Risk for recurrent venous thromboembolism reduced for patients with isolated distal DVT receiving six additional weeks of rivaroxaban

Medical Masks Similar to N95 Respirators for Preventing COVID-19

No significant difference seen with medical masks versus N95 respirators for health care personnel providing care to COVID-19 patients

Risk of Uterine Diseases, Cancers Up With Tamoxifen Treatment

After adjustment for confounding variables, risk of endometrial cancer was increased almost fourfold with tamoxifen treatment

Combination Treatment Beneficial in Albuminuric CKD

7.4 year gain in event-free survival for 50-year-old patients with combo therapy with ACEi/ARB and SGLT2 inhibitors

Antidepressants Have Small Benefit for Pain, Function in OA

However, total adverse events occur more often in patients receiving antidepressants versus placebo

FDA Approves First Gene Therapy for Adults With Hemophilia B

Benefits include decreased need for routine factor IX replacement prophylaxis and reduction in annualized bleeding rate

QOL Up With Pembrolizumab Versus Ipilimumab, HDI in Resected Melanoma

Quality of life favored the pembrolizumab arm versus standard-of-care arm receiving ipilimumab, high-dose interferon α 2b

Measles Vaccination Rates Dropped During Pandemic to 81 Percent in 2021

Number of estimated measles deaths decreased 83 percent during 2000 to 2021; estimated 56 million deaths prevented by vaccination

White House Urges COVID-19 Booster Shots Again, Citing Effectiveness

Booster vaccine adds between 30 and 56 percent more protection against getting COVID-19

Early Application of Emollients Prevents Development of Eczema

Of the types of emollient, emulsion was suggested as the better option for preventing infant atopic dermatitis development

PRIORIX, M-M-R II Vaccines Interchangeable for MMR

Either PRIORIX or M-M-R II may be administered in any situation in which MMR vaccine is indicated

Most Pivotal Trials of New Drugs Recruit From Low-, Middle-Income Countries

Percentage of participants recruited from low-, middle-income countries was 8, 36, and 17 percent for cancer, cardiovascular, neurology trials

Vitamin D Supplements Do Not Reduce Asthma Exacerbations Overall

Supplements reduce risk among children with low serum 25(OH)D and have beneficial effects in children with atopic dermatitis, allergic rhinitis

ACR: Opioids Raise Risk for VTE in Patients With Rheumatoid Arthritis

However, opioids and NSAIDs carry similar cardiovascular, mortality risks for RA patients

Treatment-Related Adverse Events of Antibody Drug Conjugates Identified

Overall incidence of treatment-related adverse events was 91.2 percent and included lymphopenia, nausea, neutropenia

Treatment Without ADT Delays Initiation of Systemic Therapy in Prostate Cancer

Metastasis-directed therapy can delay initiation of systemic therapy in patients with solitary oligorecurrent metastatic lesion

New Pfizer Booster Shot Shows Protection Against Emerging Omicron Variants

In early data, new Pfizer COVID-19 boosters marshal antibodies against newer omicron variants

FDA: Patients Should Be Cautious When Using Online Pharmacies to Buy Meds

Red flags include pharmacies that do not require a doctor's prescription or have a licensed pharmacist to answer questions

Rate of Adverse Physical Effects High With Ayahuasca Use

69.9 percent of sample reported acute physical health effects; 2.3 percent reported need for subsequent medical attention

FDA Oversight of Clinical Trials Described as 'Grossly Inadequate'

Article describes inadequate oversight relating to development of COVID-19 vaccines and predating the pandemic

FDA Moves Toward Making Overdose Antidote an Over-the-Counter Drug

If the overdose antidote drug naloxone becomes easier to obtain, it could save lives and help combat the U.S. opioid crisis

FDA Approves Drug Combo for Metastatic Non-Small Cell Lung Cancer

Approval is for tremelimumab in combination with durvalumab and platinum-based chemotherapy

Recent Increase Seen in Pediatric Benzonatate Exposure

77 percent of the cases of pediatric exposure reported to U.S. poison control centers were for unintentional exposure

Moderna Booster Shot Prompts Strong Immune Response Against Omicron Subvariants

Moderna reports its updated booster shot is indeed triggering a strong immune response to the omicron variants BA.5 and BA.4

ACAAI: Epinephrine Auto-Injector Use Low Among Adults With Food Allergy

Furthermore, one-third of adults with food allergy think epinephrine auto-injectors can cause life-threatening effects

Acupuncture Reduces Aromatase Inhibitor-Related Joint Pain

Findings observed in women with early-stage breast cancer who were taking an aromatase inhibitor and had a score of 3 or higher on BPI-WP item

Bepirovirsen Studied for Treatment of Chronic Hepatitis B Infection

Dosage regimens for bepirovirsen explored in phase 2b, randomized, investigator-unblinded trial

Eradicating H. pylori Cuts Aspirin-Related Peptic Ulcer Bleeding in the Short Term

Protection against aspirin-associated peptic ulcer bleeding in older adults lost after the first 2.5 years

Antiepileptic Med Use Increasing in Nursing Home Residents With Dementia

The two most common, valproic acid and gabapentin, being used in clinically distinct ways

Nab-Paclitaxel, Pembrolizumab Combo Active in Advanced Urothelial Cancer

Overall response rate 50 percent among 36 patients with platinum-refractory or cisplatin-ineligible advanced urothelial cancer

Remote Program Beneficial for Management of HTN, Cholesterol

Significant reductions seen in blood pressure and LDL-C at six and 12 months for patients enrolled in remote program

Options Explored for MM That Relapses After BCMA CAR T Therapy

Salvage treatments and outcomes examined for patients with multiple myeloma that relapses after B-cell maturation antigen-directed CAR T therapy

ASN: Empagliflozin Cuts Risk for Progression in CKD

Risk for progression of kidney disease or death from cardiovascular causes reduced with empagliflozin versus placebo

ASN: Discontinuation of RAS Inhibitors Does Not Increase eGFR in CKD

No difference seen with discontinuation, continuation of RAS inhibitors among patients with advanced, progressive chronic kidney disease

Delivery Methods Compared for Osteoarthritis Intervention

Pain reduction seen for in-person or digital delivery of education and exercise instruction for hip, knee osteoarthritis

Lipid-Lowering, Antidiabetic Drugs Tied to Prevalence of AMD

Use of lipid-lowering drugs, antidiabetic drugs associated with lower prevalence of any age-related macular degeneration

ENT-01 Safe, Improves Constipation in Patients With Parkinson Disease

Improvement seen in weekly complete spontaneous bowel movement rate and in secondary end points

Second, Third COVID-19 Vaccine May Up Relapse in Glomerular Disease

Absolute increase in 30-day relapse risk associated with the second or third vaccine dose is small

Pfizer Study Reveals Big Rise in Immunity From COVID-19 Booster

FDA says findings affirm its decision to approve the booster without human testing based on experience with a similarly tweaked vaccine

Dapagliflozin May Be Cost-Effective for Treating CKD

Dapagliflozin for the treatment of chronic kidney disease cost-effective at willingness-to-pay thresholds of $27,510 and $35,503 per QALY in U.K. and Germany, Spain

CDC Updates Recommendations for Prescribing Opioids for Pain

Benefits and risk of all treatment options should be considered in the context of patient circumstances

Routine Vaccination Coverage Decreased in 2021 Worldwide

Coverage levels for three doses of DTP-containing vaccine, measles-containing vaccine down to lowest levels since 2008

Brentuximab Vedotin + Chemo Ups Event-Free Survival in Peds Hodgkin Lymphoma

Event-free survival rate higher in pediatric patients, but no difference seen in the percentage of patients receiving involved-site radiation therapy

Telehealth Tied to Higher Buprenorphine Retention

Substantial number of Veterans Health Administration patients received buprenorphine from phone-only telehealth

CVS, Walgreens Announce $10 Billion Opioid Settlements

Most of the money will go toward programs that expand treatment for addiction, provide overdose antidotes, support prevention efforts